Species Human Entrez 338382 | Human Mouse Ensembl ENSG00000276600 | |
Aliases RAB7B, RAB7, member RAS oncogene family External IDs MGI: 2442295 HomoloGene: 64833 GeneCards: RAB7B | ||
Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.
Function
Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells. By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.
References
RAB7B Wikipedia(Text) CC BY-SA