Rühle is a German surname. Notable people with the surname include:
Alice Rühle-Gerstel (1894–1943), German-Jewish writer, feminist, and psychologistAugust Otto Rühle von Lilienstern (1780–1847), Prussian officerFrank Rühle (born 1944), German rower who competed for East Germany both in the 1968 and 1972 Summer OlympicsHeide Rühle (born 1948), German politician and Member of the European ParliamentHugo Rühle (1824–1888), German physicianOtto Rühle (1874–1943), German council communistStephanie Ruhle (born 1975), managing editor and news anchor for Bloomberg Television and editor-at-large for Bloomberg NewsTobias Rühle (born 1991), German footballerVern Ruhle, (1951–2007) former American right-handed pitcher and coach in Major League Baseball