Rühle is a German surname. Notable people with the surname include:
Alice Rühle-Gerstel (1894–1943), German-Jewish writer, feminist, and psychologist
August Otto Rühle von Lilienstern (1780–1847), Prussian officer
Frank Rühle (born 1944), German rower who competed for East Germany both in the 1968 and 1972 Summer Olympics
Heide Rühle (born 1948), German politician and Member of the European Parliament
Hugo Rühle (1824–1888), German physician
Otto Rühle (1874–1943), German council communist
Stephanie Ruhle (born 1975), managing editor and news anchor for Bloomberg Television and editor-at-large for Bloomberg News
Tobias Rühle (born 1991), German footballer
Vern Ruhle, (1951–2007) former American right-handed pitcher and coach in Major League Baseball