Quine is a Manx surname. Notable people with the surname include:
Edgar Quine (born 1934), Manx politicianJohn Quine (1857-1940), Manx clergyman, scholar and writer - author of The Captain of the ParishRichard Quine (1920–1989), American stage, film, and radio actor and film directorRobert Quine (1942–2004), American guitaristWillard Van Orman Quine (1908–2000), American analytic philosopher and logicianWilliam Edward Quine (1847–1922), Manx American physician and academic