Quackenbush is a surname. Notable people with the surname include:
Bill Quackenbush (1922–1999), Canadian professional hockey playerChuck Quackenbush (born 1954), American politician from California; state insurance commissioner and state assemblymanDave Quackenbush (contemporary), American punk rock singerHenry Quackenbush (1847–1933), American industrialistJohn A. Quackenbush (1828–1908), American politician from New York; U.S. representative 1888–1893John Quackenbush (born 1962), American computational biologist and genome scientistJustin Lowe Quackenbush (born 1929), American juristKevin Quackenbush (born 1988), American baseball playerMax Quackenbush (born 1928), Canadian professional hockey playerMike Quackenbush (born 1976), American professional wrestlerRobert Quackenbush (born 1929), American children's authorRobert Quackenbush (Wisconsin politician), (1923–2006) American politicianSandra Quackenbush (contemporary), American virologist