Quackenbush is a surname. Notable people with the surname include:
Bill Quackenbush (1922–1999), Canadian professional hockey player
Chuck Quackenbush (born 1954), American politician from California; state insurance commissioner and state assemblyman
Dave Quackenbush (contemporary), American punk rock singer
Henry Quackenbush (1847–1933), American industrialist
John A. Quackenbush (1828–1908), American politician from New York; U.S. representative 1888–1893
John Quackenbush (born 1962), American computational biologist and genome scientist
Justin Lowe Quackenbush (born 1929), American jurist
Kevin Quackenbush (born 1988), American baseball player
Max Quackenbush (born 1928), Canadian professional hockey player
Mike Quackenbush (born 1976), American professional wrestler
Robert Quackenbush (born 1929), American children's author
Robert Quackenbush (Wisconsin politician), (1923–2006) American politician
Sandra Quackenbush (contemporary), American virologist