Samiksha Jaiswal (Editor)

QMPSB

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Legal status
  
CA: Schedule II

PubChem CID
  
3929482

UNII
  
55Q8B94HS5

CAS Number
  
312606-87-4

ChemSpider
  
3151524

ChEMBL
  
CHEMBL245876

QMPSB httpsuploadwikimediaorgwikipediacommonsthu

QMPSB is an arylsulfonamide-based synthetic cannabinoid that has been sold as a designer drug.

QMPSB was first discovered by Lambeng and colleagues in 2007. It acts as a full agonist of the CB1 receptor and CB2 receptor with Ki values of 3 nM and 4 nM, respectively. A large number of related derivatives were subsequently produced, with the main focus of this work being to increase selectivity for the non-psychoactive CB2 receptor. This work led on from an earlier series of sulfamoyl benzamide derivatives for which a patent was filed in 2004.

The quinolin-8-yl ester motif of QMPSB led to the discovery of other designer cannabinoids such as PB-22 and BB-22.

References

QMPSB Wikipedia