Pyrimidine oxygenase

Updated on Dec 26, 2024

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EC number 1.14.99.46 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

Pyrimidine oxygenase (EC 1.14.99.46, RutA) is an enzyme with systematic name uracil,FMNH₂:oxygen oxidoreductase (uracil hydroxylating, ring-opening) . This enzyme catalyses the following chemical reaction

(1) uracil + FMNH₂ + O₂ ⇌ (Z)-3-ureidoacrylate peracid + FMN(2) thymine + FMNH₂ + O₂ ⇌ (Z)-2-methylureidoacrylate peracid + FMN

In vitro the product (Z)-3-ureidoacrylate peracid is spontaneously reduced to ureidoacrylate.

References

Pyrimidine oxygenase Wikipedia

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