Pyne is a surname. Notable people with the surname include:
Bernard Pyne GrenfellChris PyneChristopher PyneDouglas PyneFrederick PyneGanesh PyneGeorge Pyne (disambiguation), multiple peopleJames Baker PyneJames Kendrick PyneJim PyneJoe PyneJohn PyneKen Pyne, British cartoonistLouisa Pyne (1832–1904), English soprano and opera company managerMoses Taylor PyneNatasha PyneParker PynePercy PynePercy Rivington Pyne (disambiguation)Richard PyneRob PyneRobert Allan PyneStephen J. PyneTom PyneWilliam Henry Pyne