Pybus is a surname. Notable people with this name include:
Cassandra Pybus (born 1947), an Australian historian and author
Dave Pybus (born 1970), English bassist with Cradle of Filth
Frederick Charles Pybus, English surgeon noted for research into organ transplantation
Sir Percy John Pybus, 1st Baronet (1880–1935), known as John Pybus, British Liberal Party politician
Richard Pybus (born 1964), English-born cricket coach
William Richard Pybus (1848–1917), South Australian organist
