EC number 4.2.1.70 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 9023-35-2 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a pseudouridylate synthase (EC 4.2.1.70) is an enzyme that catalyzes the chemical reaction
uracil + D-ribose 5-phosphateThus, the two substrates of this enzyme are uracil and D-ribose 5-phosphate, whereas its two products are pseudouridine 5'-phosphate and H2O.
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is uracil hydro-lyase (adding D-ribose 5-phosphate pseudouridine-5'-phosphate-forming). Other names in common use include pseudouridylic acid synthetase, pseudouridine monophosphate synthetase, 5-ribosyluracil 5-phosphate synthetase, pseudouridylate synthetase, upsilonUMP synthetase, and uracil hydro-lyase (adding D-ribose 5-phosphate). This enzyme participates in pyrimidine metabolism.
Structural studies
As of late 2007, 22 structures have been solved for this class of enzymes, with PDB accession codes 1DJ0, 1K8W, 1KSK, 1KSL, 1KSV, 1PRZ, 1QYU, 1R3E, 1R3F, 1SB7, 1SGV, 1SI7, 1SZW, 1V9F, 1V9K, 1VIO, 1XPI, 1Z2Z, 1ZE1, 1ZE2, 1ZL3, and 2I82.