Protogeneia (Ancient Greek: Πρωτογένεια "the firstborn"), in Greek mythology, may refer to:
Protogeneia, a daughter of Deucalion and Pyrrha, progenitors in Greek mythology. She was married to Locrus, but had no children; Zeus, however, who carried her off, became by her, on mount Maenalus in Arcadia, the father of Opus, Aethlius and Aetolus. According to others she was not the mother, but a daughter of Opus. Endymion also is called a son of Protogeneia.
Protogeneia, a daughter of Calydon and Aeolia. With Ares, she was mother to Oxylus of Aetolia.
Protogeneia, one of the daughters of Erechtheus and Praxithea. She and her sister Pandora committed suicide when Erechtheus sacrificed Chthonia, another sister of theirs.
