Symbol PROK1 HUGO 18454 RefSeq NM_032414 | Entrez 84432 OMIM 606233 UniProt P58294 | |
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Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.
Recently, prokineticins have been recognized in humans and other vertebrates. They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception. Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.
Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.
References
Prokineticin Wikipedia(Text) CC BY-SA