Girish Mahajan (Editor)

Proglucagon

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit

Proglucagon is a protein that is cleaved from preproglucagon. Preproglucagon in humans is encoded by the GCG gene.

Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distal ileum and colon. It is cleaved into the following components:

  • Glicentin
  • Glicentin-related pancreatic polypeptide (GRPP)
  • Oxyntomodulin (OXY or OXM)
  • Glucagon
  • Glucagon-like peptide 1 (GLP-1)
  • Glucagon-like peptide 2 (GLP-2)

    • References

    Proglucagon Wikipedia
    (Text) CC BY-SA