Puneet Varma (Editor)

Proamanullin

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Formula
  
C39H54N10O11S

Appearance
  
Colorless, odorless

Molar mass
  
870.97 g/mol

Proamanullin

Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms.

Toxicology

Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).

References

Proamanullin Wikipedia