Prisco is both a given name and surname. Notable people with the name include:
Prisco Nilo (born 1957), Filipino meteorologistAlbert Prisco (1890–?), American actorAngelo Prisco (born 1939), American mobsterGiulio Prisco (born 1957), Italian physicistGiuseppe Antonio Ermenegildo Prisco (1833–1923), Italian cardinalLorenzo Prisco (born 1987), Italian footballerMichele Prisco (1920–2003), Italian journalistNick Prisco (1909–1981), American football playerTeodoro "Prisco" Alcalde Millos (1913–1995), Peruvian footballer