Samiksha Jaiswal (Editor)

Prinomastat

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ATC code
  
None

CAS Number
  
192329-42-3

IUPHAR/BPS
  
6505

Molar mass
  
423.5 g/mol

Biological half-life
  
1–5 hours

PubChem CID
  
466151

ChemSpider
  
409762

Prinomastat httpsuploadwikimediaorgwikipediacommonsthu

Pronounce medical words prinomastat


Prinomastat (code name AG-3340) is a matrix metalloproteinase (MMP) inhibitor with specific selectivity for MMPs 2, 3, 9, 13, and 14. Investigations have been carried out to determine whether the inhibition of these MMPs is able to block tumour metastasis by preventing MMP degradation of the extracellular matrix proteins and angiogenesis. Prinomastat underwent a Phase III trial to investigate its effectiveness against non-small cell lung cancer (NSCLC), in combination with gemcitabine chemotherapy. However, it was discovered that Prinomastat did not improve the outcome of chemotherapy in advanced non-small-cell lung cancer.

References

Prinomastat Wikipedia


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