Primary age-related tauopathy (PART) is a new neuropathological designation used to describe the neurofibrillary tangles that are commonly observed in the brains of elderly individuals that can occur independently of the amyloid plaques of Alzheimer's disease. Patients with severe PART typically exhibit mild cognitive impairment or an amnestic. At autopsy, they display Alzheimer's-type NFT, predominantly in the medial temporal lobe, but no amyloid-beta peptide accumulation in plaques.
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Primary age-related tauopathy Wikipedia(Text) CC BY-SA