Samiksha Jaiswal (Editor)

Prephenate dehydratase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
4.2.1.51

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
9044-88-6

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a prephenate dehydratase (EC 4.2.1.51) is an enzyme that catalyzes the chemical reaction

prephenate phenylpyruvate + H2O + CO2

Hence, this enzyme has one substrate, prephenate, but 3 products: phenylpyruvate, H2O, and CO2.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming). This enzyme is also called prephenate hydro-lyase (decarboxylating). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QMX.

References

Prephenate dehydratase Wikipedia