Entrez 5073 | Ensembl n/a | |
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Aliases PARN, DAN, DKCB6, PFBMFT4, Poly(A)-specific ribonuclease External IDs MGI: 1921358 HomoloGene: 31098 GeneCards: PARN | ||
Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.
Function
Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases. The protein appears to be localized in both the nucleus and the cytoplasm. It is not stably associated with polysomes or ribosomal subunits.
References
Poly(A)-specific ribonuclease Wikipedia(Text) CC BY-SA