Polidori is an Italian surname. Notable people with the surname include:
Ambra Polidori, Mexican artist
Frances Polidori, daughter of Gaetano, mother of Maria, Dante, William and Christina Rossetti
Gaetano Polidori, Italian writer
Giancarlo Polidori, Italian cyclist
Gino Polidori, American politician
John William Polidori, Italian-English physician and writer, son of Gaetano
Paolo Polidori, Italian cardinal
Robert Polidori, Canadian photographer