Girish Mahajan (Editor)

Policosanol

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ATC code
  
C10AX08 (WHO)

ChemSpider
  
none

Formula
  
CH3-(CH2)n-CH2OH n=24-34

CAS Number
  
142583-61-7

Molar mass
  
(variable)

Policosanol

AHFS/Drugs.com
  
International Drug Names

Policosanol is the generic term for a mixture of long chain alcohols extracted from plant waxes. It is used as a dietary supplement.

Policosanol was originally derived from sugar cane but the chemicals can also be isolated from beeswax, cereal grains, grasses, leaves, fruits, nuts, and seeds of many foods. Plant waxes consist of very long chain fatty acids that have been esterified to very long chain alcohols. Policosanols are very long chain alcohols with carbon backbones ranging from 24 to 34 carbons.

The first policosanol supplements were produced by Dalmer Laboratories in Cuba; studies conducted and published by that group have found that policosanol is safe and effective as a lipid-lowering agent. However these studies were small, and efforts by groups outside of Cuba have failed to replicate these results.

Meta-analysis in 2005 found that human policosanol consumption is safe and well tolerated and is effective at lowering the blood cholesterol. As of 2010, they were marketed as lipid-lowering agents in the Caribbean, Central and South America, and Canada.

References

Policosanol Wikipedia


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