Poku is a surname. Notable people with the surname include
Ernest Owusu-Poku, Ghanaian police officer
Fritz Kwabena Poku, Ghanaian diplomat
Godfrey Poku (born 1990), English footballer
Kwadwo Poku (born 1985), Ghanaian footballer
Kwadwo Poku (born 1992), Ghanaian footballer
Kwame Sanaa-Poku Jantuah (1922–2011), Ghanaian politician and diplomat
Nana Poku (born 1988), Ghanaian footballer