Plumbagin

Updated on Dec 10, 2024

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Formula C11H8O3		Molar mass 188.1794 g/mol

Plumbagin or 5-hydroxy-2-methyl-1,4-naphthoquinone is an organic compound with the chemical formula C
11H
8O
3. It is regarded as a toxin and it is genotoxic and mutagenic.

Plumbagin Plumbagin quantification in roots of Plumbago scandens L obtained

Plumbagin is a yellow dye, formally derived from naphthoquinone.

It is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe.

Plumbagin httpsuploadwikimediaorgwikipediacommonsthu

Pharmacologic properties

The following properties were described in various cellular and animal models:

antimicrobial,

antimalarial,

anti-inflammatory,

anticarcinogenic,

cardiotonic,

immunosuppressive,

antifertility action,

neuroprotective,

anti-atherosclerosis effects.

Plumbagin has been shown to induce cell cycle arrest and apoptosis in numerous cancer cell lines including melanoma, lung, breast and others. It triggers autophagy via inhibition of the Akt/mTOR pathway and induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner.

Positive inotropic activity

Enzymatic spectrum of herbal plants Plumbago Linn.

Bioactive spectra of plumbagin.

Effect on root- knot nematode Meloidogyne spp.

References

Plumbagin Wikipedia

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