Pistone is an Italian surname. Notable people with the surname include:
Alessandro Pistone (born 1975), Italian footballer
Anita Pistone (born 1976), Italian sprinter
Chase Pistone (born 1983), American racing driver
Joseph D. Pistone (born 1939), American FBI agent and writer
Pete Pistone (born 1964), American motorsports journalist and commentator
Tom Pistone (born 1929), American racing driver