CAS Number 946846-83-9 ChemSpider 32700981 Formula C17H16N2O4 | PubChem CID 24815904 3D model (Jmol) Interactive image Molar mass 312.32 g/mol | |
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Piromelatine can it fight alzheimer s by promoting sleep
Piromelatine (Neu-P11) is a multimodal sleep drug under development by Neurim Pharmaceuticals. It is an agonist at melatonin MT1/MT2 and serotonin 5-HT1A/5-HT1D receptors. Neurim is conducting a phase II randomized, placebo controlled trial of cognitive and sleep effects in Alzheimer's disease.
Results of a phase II trial on insomnia in 120 adults were announced in 2013, finding piromelatine 20/50 mg improved sleep over 4 weeks vs placebo. Phase 1A/1B studies in 2011, showed safe dose-dependent improvement in sleep. Pre-clinical studies showed antinociceptive antihypertensive and cognitive benefits in rat disease models of pain, hypertension, and Alzheimer's disease.
References
Piromelatine Wikipedia(Text) CC BY-SA