Girish Mahajan (Editor)

Piquindone

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Routes of administration
  
Oral

CAS Number
  
78541-97-6

ChemSpider
  
108751

ATC code
  
none

PubChem CID
  
121903

Molar mass
  
246.35 g/mol

Piquindone httpsuploadwikimediaorgwikipediacommonsthu

Legal status
  
In general: uncontrolled

How to pronounce piquindone


Piquindone (Ro 22-1319) is an atypical antipsychotic with a tricyclic structure that was developed in the 1980s but was never marketed. It acts as a selective D2 receptor antagonist, though based on its effects profile its selectivity may be considered controversial. Unlike most other D2 receptor ligands, piquindone displays Na2+-dependent binding, a property it shares with tropapride, zetidoline, and metoclopramide.

In clinical trials piquindone was found to possess moderate efficacy in treating positive symptoms of schizophrenia, and notably, was also modestly effective for negative symptoms, though this was just under statistical significance. Additionally, relative to haloperidol, it was found to possesses significantly fewer extrapyramidal symptoms and had a much lower propensity for inducing tardive dyskinesia, indicating its atypical nature. In addition to psychosis, piquindone has also been found to be effective in the treatment of Tourette's syndrome in numerous clinical studies.

References

Piquindone Wikipedia