Pierson is a surname. Notable people with the surname include:
Abraham Pierson, the elder (died 1678), English pastor in New EnglandAbraham Pierson (1646-1707), pastor, and first rector and a founder of what would become Yale University, son of Abraham Pierson, the elderArthur Tappan Pierson, Presbyterian pastor and authorClara D. Pierson, American children's book authorDon Pierson, American broadcasting pioneerEmma Pierson (born 1981), British actressFrank Pierson, American film directorHenry Hugh Pierson , composer (1815-1873)Henry R. Pierson (1819–1890), New York politicianJulia Pierson, the 23rd Director of the U. S. Secret ServiceKate Pierson, American singer, of The B-52'sLeander J. Pierson, American politicianMelissa Holbrook Pierson, American authorNicolaas Pierson, the 23rd Prime Minister of the NetherlandsPhilippe Pierson, Belgian JesuitRex Pierson, English aircraft designerRobert H. Pierson, former president of the General Conference of Seventh-day AdventistsWilliam Pierson (1926–2004), American actorWilliam Pierson, Jr. (1911–2008), American painterWilliam Pierson (baseball) (1899–1959), American baseball playerWilliam Montgomery Pierson (1842–1890), American jurist, senator, co-founder of the San Francisco Bar Association, and notable amateur astronomer