Pierson is a surname. Notable people with the surname include:
Abraham Pierson, the elder (died 1678), English pastor in New England
Abraham Pierson (1646-1707), pastor, and first rector and a founder of what would become Yale University, son of Abraham Pierson, the elder
Arthur Tappan Pierson, Presbyterian pastor and author
Clara D. Pierson, American children's book author
Don Pierson, American broadcasting pioneer
Emma Pierson (born 1981), British actress
Frank Pierson, American film director
Henry Hugh Pierson , composer (1815-1873)
Henry R. Pierson (1819–1890), New York politician
Julia Pierson, the 23rd Director of the U. S. Secret Service
Kate Pierson, American singer, of The B-52's
Leander J. Pierson, American politician
Melissa Holbrook Pierson, American author
Nicolaas Pierson, the 23rd Prime Minister of the Netherlands
Philippe Pierson, Belgian Jesuit
Rex Pierson, English aircraft designer
Robert H. Pierson, former president of the General Conference of Seventh-day Adventists
William Pierson (1926–2004), American actor
William Pierson, Jr. (1911–2008), American painter
William Pierson (baseball) (1899–1959), American baseball player
William Montgomery Pierson (1842–1890), American jurist, senator, co-founder of the San Francisco Bar Association, and notable amateur astronomer
