Piccoli is an Italian surname. Notable people with the surname include:
Adrian Piccoli (born 1970), Australian politician
Anselmo Piccoli (1915–1992), Argentine artist
Fantasio Piccoli (1917–1981), Italian stage director
Flaminio Piccoli (1918–2000), Italian politician
Francesco De Piccoli (born 1937), Italian boxer
Ivan Piccoli (born 1981), Italian footballer
Mariano Piccoli (born 1970), Italian cyclist
Michel Piccoli (born 1925), French actor
Nestor Omar Piccoli (born 1965), Argentine footballer
Nino Piccoli, Italian racing driver
