Piccinini is an Italian surname. Notable people with the surname include:
Alberto Piccinini (1923 − 1972 in Rome), Italian professional football player.
Alessandro Piccinini (1566 – ca. 1638), Italian lutenist and composer.
Amelia Piccinini (1917 – 1979), Italian athlete.
Eduardo Piccinini (1968), Brazilian butterfly swimmer.
Francesca Piccinini (1979), Italian volleyball player.
Gaetano Piccinini (1904 – 1972), Italian priest of the Don Orione Congregation.
Gualtiero Piccinini (1970), Italian and American philosopher.
Marco Piccinini (1952), Monegasque personality, businessman and politician.
Marina Piccinini (1968), Italian American virtuoso flautist.
Patricia Piccinini (1965), Australian artist.
