Piccinini is an Italian surname. Notable people with the surname include:
Alberto Piccinini (1923 − 1972 in Rome), Italian professional football player.Alessandro Piccinini (1566 – ca. 1638), Italian lutenist and composer.Amelia Piccinini (1917 – 1979), Italian athlete.Eduardo Piccinini (1968), Brazilian butterfly swimmer.Francesca Piccinini (1979), Italian volleyball player.Gaetano Piccinini (1904 – 1972), Italian priest of the Don Orione Congregation.Gualtiero Piccinini (1970), Italian and American philosopher.Marco Piccinini (1952), Monegasque personality, businessman and politician.Marina Piccinini (1968), Italian American virtuoso flautist.Patricia Piccinini (1965), Australian artist.