Girish Mahajan (Editor)

Phyloscan

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Platform
  
web service

Type
  
Bioinformatics tool

Available in
  
English

Developer(s)
  
Wadsworth Center, New York State Department of Health

Initial release
  
March 14, 2005 (2005-03-14)

Stable release
  
2.2 / January 28, 2010 (2010-01-28)

Phyloscan is a web service for DNA sequence analysis that is free and open to all users (without login requirement). For locating matches to a user-specified sequence motif for a regulatory binding site, Phyloscan provides a statistically sensitive scan of user-supplied mixed aligned and unaligned DNA sequence data. Phyloscan's strength is that it brings together

  • the Staden method for computing statistical significance,
  • the "phylogenetic motif model" scanning functionality of the MONKEY software that models evolutionary relationships among aligned sequences,
  • the use of the Bailey & Gribskov method for combining statistics across non-aligned sequence data, and
  • the Neuwald & Green technique for combining statistics across multiple binding sites found within a single gene promoter region.

    • References

    Phyloscan Wikipedia
    (Text) CC BY-SA