Kalpana Kalpana (Editor)

Phospholipid hydroperoxide glutathione peroxidase

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EC number
  
1.11.1.12

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

Classification
  
Glutathione peroxidase

CAS number
  
97089-70-8

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

Gene ontology
  
0047066

In enzymology, a phospholipid-hydroperoxide glutathione peroxidase (EC 1.11.1.12) is an enzyme that catalyzes the chemical reaction

2 glutathione + a lipid hydroperoxide glutathione disulfide + lipid + 2 H2O

Thus, the two substrates of this enzyme are glutathione and lipid hydroperoxide, whereas its 3 products are glutathione disulfide, lipid, and H2O.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is glutathione:lipid-hydroperoxide oxidoreductase. Other names in common use include peroxidation-inhibiting protein, PHGPX, peroxidation-inhibiting protein: peroxidase, glutathione, (phospholipid hydroperoxide-reducing), phospholipid hydroperoxide glutathione peroxidase, hydroperoxide glutathione peroxidase, or glutathione peroxidase 4 (GPX4). This enzyme participates in glutathione metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2GS3 and 2OBI.

References

Phospholipid-hydroperoxide glutathione peroxidase Wikipedia