EC number 2.7.3.9 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 37278-17-4 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) is an enzyme that catalyzes the chemical reaction
phosphoenolpyruvate + protein histidineThus, the two substrates of this enzyme are phosphoenolpyruvate and protein histidine, whereas its two products are pyruvate and protein Npi-phospho-L-histidine.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. The systematic name of this enzyme class is phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase. Other names in common use include phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, sugar-PEP phosphotransferase enzyme I, and phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase. This enzyme participates in phosphotransferase system (pts).
Structural studies
As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1EZA, 1EZB, 1EZC, 1EZD, 1ZYM, 2EZA, 2EZB, 2EZC, 2HRO, 2HWG, 3EZA, 3EZB, and 3EZE.