EC number 4.6.1.13 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 37288-19-0 BRENDA BRENDA entry KEGG KEGG entry | |
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In enzymology, a phosphatidylinositol diacylglycerol-lyase (EC 4.6.1.13) is an enzyme that catalyzes the chemical reaction
1-phosphatidyl-1D-myo-inositolHence, this enzyme has one substrate, 1-phosphatidyl-1D-myo-inositol, and two products, 1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.
This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase, (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase, and (1,2-cyclic-phosphate-forming). This enzyme participates in inositol phosphate metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T6M and 2OR2.