EC number 2.7.1.154 BRENDA BRENDA entry KEGG KEGG entry | IntEnz IntEnz view ExPASy NiceZyme view MetaCyc | |
In enzymology, a phosphatidylinositol-4-phosphate 3-kinase (EC 2.7.1.154) is an enzyme that catalyzes the chemical reaction
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphateThus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase. Other names in common use include type II phosphoinositide 3-kinase, C2-domain-containing phosphoinositide 3-kinase, and phosphoinositide 3-kinase. This enzyme participates in phosphatidylinositol signaling system.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2AR5, 2B3R, and 2IWL.