Samiksha Jaiswal (Editor)

Phosducin

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Species
  
Entrez
  
5132

Human
  
Ensembl
  
ENSG00000116703

Phosducin

Aliases
  
PDC, MEKA, PHD, PhLOP, PhLP, phosducin

External IDs
  
MGI: 98090 HomoloGene: 1950 GeneCards: PDC

Phosducin, also known as PDC, is a human protein and gene. It belongs to phosducin family of proteins.

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. By associating with these subunits only, the Transducin alpha subunit will remain active for longer. This will increase the amount of time of visual excitation.

This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.

References

Phosducin Wikipedia


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