Phenylacetyl CoA 1,2 epoxidase

Phenylacetyl-CoA 1,2-epoxidase (EC 1.14.13.149, ring 1,2-phenylacetyl-CoA epoxidase, phenylacetyl-CoA monooxygenase, PaaAC, PaaABC(D)E) is an enzyme with systematic name phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing). This enzyme catalyses the following chemical reaction

phenylacetyl-CoA + NADPH + H⁺ + O₂ ⇌ 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP⁺ + H₂O

Phenylacetyl-CoA 1,2-epoxidase participates in catabolism of phenylacetate in Escherichia coli and Pseudomonas putida.