ATC code none PubChem CID 5362458 Molar mass 347.493 g/mol | CAS Number 468-07-5 ChemSpider 16735962 | |
Legal status AU: S9 (Prohibited)CA: Schedule IDE: Anlage I (Controlled)UK: Class AUS: Schedule I Synonyms (-)-3-hydroxy- N- (2-phenylethyl) morphinan | ||
Phenomorphan is an opioid analgesic. It is not currently used in medicine, but has similar side-effects to other opiates, which include itching, nausea and respiratory depression.
Phenomorphan is a highly potent drug due to the N-phenethyl group, which boosts affinity to the μ-opioid receptor, and so phenomorphan is around 10x more potent than levorphanol, which is itself 6-8x the potency of morphine. Other analogues where the N-(2-phenylethyl) group has been replaced by other aromatic rings. are even more potent, with the N-(2-(2-furyl)ethyl) and the N-(2-(2-thienyl)ethyl) analogues being 60x and 45x stronger than levorphanol, respectively.
References
Phenomorphan Wikipedia(Text) CC BY-SA