Petrillo is a surname. Some people with this surname include:
Alessio De Petrillo, Italian football player and coachAndi Petrillo, Canadian hockey broadcasterFerdinando De Petrillo, Italian boxer who competed in the 1924 Summer OlympicsJames Petrillo (1892–1984), leader of the American Federation of MusiciansLuigi Petrillo (1903–1964), Italian pentathleteSammy Petrillo (1934–2009), American comedian best known as a Jerry Lewis lookalike