Pertactin

In molecular biology, pertactin (PRN) is a highly immunogenic virulence factor of Bordetella pertussis, the bacterium that causes pertussis. Specifically, it is an outer membrane protein that promotes adhesion to tracheal epithelial cells. PRN is purified from Bordetella pertussis and is used for the vaccine production as one of the important components of acellular pertussis vaccine.

A large part of the N-terminus of the pertactin protein is composed of beta helix repeats. This region of the pertactin protein is secreted through the C-terminal autotransporter.