Persse is a surname. Notable people with the surname include:
Atty Persse (1869-1960), Champion English racehorse trainerDudley Persse (1625–1699), Anglo-Irish landlordHenry Persse (1885–1918), English cricketerHenry Stratford Persse (died 1833), Irish writerIsabella Augusta Persse (best known as Lady Gregory; 1852–1932), Anglo-Irish playwright, poet, translator and chatelaineLee-Ann Persse (born 1988), South African rowerSarah Persse (fl. 1899), Irish women's rights activistWilliam Persse (ca. 1728–1802), Irish volunteer