Persons is a surname. Notable people with the surname include:
Robert Persons (1546–1610), English Jesuit priestEll Persons, African American lynched in 1917Enos Warren Persons (1836–1899), American politicianGordon Persons (1902–1965), American politician and 43rd Governor of AlabamaHenry Persons (1834–1910), American politician, lawyer, and soldierPeter Persons (born 1962), American professional golferWilton Persons (1896–1977), White House Chief of Staff to President Dwight D. Eisenhower