Puneet Varma (Editor)

Peptidylglycine alpha amidating monooxygenase

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Species
  
Entrez
  
5066

Human
  
Ensembl
  
ENSG00000145730

Peptidylglycine alpha-amidating monooxygenase

Aliases
  
PAM, PAL, PHM, Peptidylglycine alpha-amidating monooxygenase

External IDs
  
MGI: 97475 HomoloGene: 37369 GeneCards: PAM

Peptidyl-glycine alpha-amidating monooxygenase is an enzyme that, in humans, is encoded by the PAM gene.

Function

This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences are not yet known.

References

Peptidylglycine alpha-amidating monooxygenase Wikipedia


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