Peptidyl glutamate 4 carboxylase

Peptidyl-glutamate 4-carboxylase (EC 4.1.1.90, vitamin K-dependent carboxylase, gamma-glutamyl carboxylase) is an enzyme with systematic name peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing). This enzyme catalyses the following chemical reaction

peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H₂O ⇌ peptidyl-glutamate + CO₂ + O₂ + phylloquinone

The enzyme can use various vitamin-K derivatives, including menaquinone.