EC number 2.3.1.88 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 83452-29-3 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a peptide alpha-N-acetyltransferase (EC 2.3.1.88) is an enzyme that catalyzes the chemical reaction
acetyl-CoA + peptideThus, the two substrates of this enzyme are acetyl-CoA and peptide, whereas its two products are Nalpha-acetylpeptide and CoA.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:peptide Nalpha-acetyltransferase. Other names in common use include beta-endorphin acetyltransferase, peptide acetyltransferase, protein N-terminal acetyltransferase, NAT, Nalpha-acetyltransferase, amino-terminal amino acid-acetylating enzyme, and acetyl-CoA:peptide alpha-N-acetyltransferase.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2OB0 and 2PSW.