Pentalenolactone synthase

Pentalenolactone synthase (EC 1.3.7.10, penM (gene), pntM (gene)) is an enzyme with systematic name pentalenolactone-F:oxidized-ferredoxin oxidoreductase (pentalenolactone forming). This enzyme catalyse the following chemical reaction

pentalenolactone F + oxidized ferredoxin ⇌ pentalenolactone + reduced ferredoxin

This is heme-thiolate protein (P-450), which is isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae.