Pentalenolactone F synthase

Pentalenolactone F synthase (EC 1.14.11.36, PEND (gene), PNTD (gene), PTLD (gene)) is an enzyme with systematic name pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase. This enzyme catalyses the following chemical reaction

pentalenolactone D + 2 2-oxoglutarate + 2 O₂ ⇌ pentalenolactone F + 2 succinate + 2 CO₂ + H₂O (overall reaction)(1a) pentalenolactone D + 2-oxoglutarate + O₂ ⇌ pentalenolactone E + succinate + CO₂ + H₂O(1b) pentalenolactone E + 2-oxoglutarate + O₂ ⇌ pentalenolactone F + succinate + CO₂

Pentalenolactone F synthase contains Fe(II), and ascorbate is needed for its action.