Pena is a surname. Notable people with the surname include:
Danny Pena (born 1968), American soccer player
Gilbert Pena (born 1949), American politician
Javier Pena, one of the DEA agents who captured and killed Pablo Escobar, and a principal character in the Netflix series Narcos
Marius Pena (born 1985), Romanian soccer player
Paul Pena (1950–2005), American singer