Pellegrino is a surname. Notable people with the surname include:
Adriano Pellegrino (born 1984), Australian football player
Aline Pellegrino (born 1982), Brazilian football player
Charles R. Pellegrino (born 1953), American author
Edmund D. Pellegrino, American, chairman of the President's Council on Bioethics
Frank Pellegrino (inventor), president of General Fibre Company and plastic molding machine inventor.
Frank Pellegrino (actor), American actor
Frank P. Pellegrino, philanthropist and former president and chairman of International Hat Company
Giovanni Pellegrino (born 1939), Italian politician
Kurt Pellegrino (born 1979), American mixed martial artist
Mark Pellegrino (born 1965), American actor
Mauricio Pellegrino (born 1971), Argentine football player
Maximiliano Pellegrino (born 1980), Argentine football player
Michele Pellegrino (1903–1986), Italian archbishop
San Danielo da Pellegrino (ca. 1480-1545), Italian painter
Vincenzo Pellegrino, English actor
