Peguero is a Spanish surname. Notable people with this surname include:
Arismendy Peguero (born 1980), Dominican sprinter
Carlos Peguero (born 1987), Dominican baseball left fielder in Major League Baseball
Francisco Peguero (born 1988), Dominican baseball outfielder
Jailen Peguero (born 1981), Dominican baseball relief pitcher
Julio Peguero (born 1968), Dominican retired baseball outfielder
Olivia Peguero (born 20th century), Dominican artist
Peguero Jean Philippe (also known as Jean Philippe Peguero; born 1981), Haitian footballer
