Starting at Alexandra Road, Pasir Panjang Road continues to Clementi Road where it becomes West Coast Road. Since the building of the West Coast Highway, Pasir Panjang Road has become a secondary road which now has less traffic.
The road passes through many developments built over a long period, ranging from some intact Malay kampong houses which were displaced from the Kallang Basin area in the 1930s (many of which have since been demolished), numerous villas, modern apartment and condominiums, Tiger Balm Gardens (now Haw Par Villa), The Haven (now the Salvation Army Pasir Panjang Corps) and Pasir Panjang Park. Pasir Panjang Park, established before World War II and about 11,800 square metres in area, is situated between Pasir Panjang Road and the wharves just past Pepys Road. At the end of Pepys Road is a small group of black and white colonial houses of the 1920s era which command a good view of the sea.
Alexandra Road was not laid out until 1864. It connected Pasir Panjang Road to River Valley Road. In the past, the road "in addition to being a useful line of communication, the side ditches improved the drainage of the neighbouring country".